急性冠脉综合征与高敏C反应蛋白及颈动脉粥样硬化的相关研究.docVIP

急性冠脉综合征与高敏C反应蛋白及颈动脉粥样硬化的相关研究 作者:欧阳菊艳, 布娃加尔·吾守 作者单位：新疆医科大学第一附属医院干部心血管二科, 新疆乌鲁木齐830054 【摘要】 　　　目的: 探讨急性冠脉综合征 (ACS)病人与高敏反应C蛋白(hsCRP)水平及颈动脉超声检查变化及其相关性。方法： 将109例观察对象分为病例组(急性冠脉综合征,56例)和对照组(53例)。采用酶联免疫吸附法(ELISA)检测血清hsCRP水平。使用多谱勒超声检查颈动脉内中膜厚度(IMT)及斑块发生率。同时将109例观察对象分为hsCRP≤3 mg/L组（43例）和hsCRP＞3 mg/L组（66例），分析hsCRP与IMT的关系。结果：病例组血清hsCRP(4.72±2.55） mg/L明显高于对照组（1.85±0.79） mg/L，差异具有统计学意义（P＜0.01）。病例组颈动脉内中膜厚度(1.82±0.66) mm，明显厚于对照组(1.01±0.40) mm，斑块发生率(85.7%)高于对照组(35.8%)，差异均具有统计学意义（P＜0.001）。hsCRP＞3 mg/L组IMT为(1.80±0.63) mm，斑块发生率为83.7%,急性冠脉综合征发生率为83.7%；hsCRP≤3 mg/L组IMT为(1.17±0.59) mm，斑块发生率为37.9%，急性冠脉综合征发生率为30.3%,２组比较差异均具有统计学意义。血清hsCRP水平与IMT厚度呈正相关（rs=0.434, P0.05）。结论： 血清hsCRP水平可作为反映急性冠脉综合征患者的敏感标志物，颈动脉粥样硬化程度可以反映急性冠脉综合征的斑块不稳定性，炎症反应可能参与颈动脉硬化形成。 【关键词】 急性冠脉综合征； 高敏C反应蛋白； 颈动脉内中膜厚度 　　A correlation study of serum high senstive C reactive protein and carotid artery atherosclerosis in patients with acute coronary syndromes 　　OURANG Juyan, Buwajiaer·Wushouer 　　(Second Department of Cadres Cardiovascular Disease, First Affiliated Hospital,Xinjiang Medical University, Urumqi 830054, China) 　　Abstract: Objective: To explore the relationship among the high senstive Creactive protein(hsCRP), carotid artery atherosclersis and the patients with acute coronary syndromes (ACS). Methods： Fifty six patiens were in ACS group, the other fifty three without coronary heart diaease were control group. The levels of hsCRP was measured by means of enzymelinkedimmonosorbentassay (ELISA). Compared with the carotid intimamedio thinkness (IMT) and carotid plague score in two groups patiens by ultrasound . Their results were analyzed by correlate analysis. Results: The levels of the hsCRP were significantly higher in ACS group than in contral group (4.72±2.55 mg/L vs 1.85±0.79 mg/L). There were significant differences in intiminmedia thickness (1.82±0.66 mm vs 1.01±0.40 mm) and the prevelence rate of atherosclerotic (85.7%vs35.8%) between the two groups. T