急性脑梗死患者血清叶酸VitB12水平及其临床意义.docVIP

急性脑梗死患者血清叶酸、VitB12水平及其临床意义 　　作者：卞鑫 刘宇 姜卓颍 胡晓勤 朱国桢　　作者单位： 200093 上海市控江医院内科 　　【摘要】 目的 探讨急性脑梗死患者血清叶酸、VitB12水平及其临床意义。方法 对88例首次发病的急性缺血性脑中风患者分为两个亚组，动脉硬化性脑梗死组32例，腔隙性脑梗死组56例，并设对照组35例，入院后用罗氏公司Elecsys 2010型全自动电化学发光免疫分析仪测定血清叶酸、VitB12浓度。结果 (1)脑梗死组、腔隙性脑梗死组的血清叶酸、VitB12平均水平均显著低于对照组(P值分别0.01、0.05);(2)脑梗死组的血清叶酸、VitB12平均水平显著低于腔隙性脑梗死组(P值均0.05)。结论 血清叶酸、VitB12可作为急性脑梗死、腔隙性脑梗死比较特异重要的监测指标，对临床鉴别脑梗死与腔隙性脑梗死有一定的帮助,并对脑梗死的预防、治疗可能有一定的指导意义。 　　关键词 脑梗死 腔隙性脑梗死 叶酸 VitB12 同型半胱氨酸 　　Level of serum folate,VitB12 and its meaning in patients with acute cerebral infarction 　　Bian Xin，Liu Yu，Jiang Zhuoying，et al. 　　Department of Neurology,Kongjiang Hospital,Shanghai 200093. 　　【Abstract】 Objective To explore the association between the level of folate,VitB12 and acute cerebral infarction disease.Methods 88 acute ischemic cerebrovascular stroke disease events were disparted in two subgroups,32 of arteriosclerotic cerebral infarction,56 of lacunar cerebral infarction,and 35 contrast group were set up.All the participants serum folate,VitB12 were measured when they entered the hospital.Results (1)The level of serum folate,VitB12 in cerebral infarction、lacunar cerebral infarction were evidently lower than contrast group.(P respectively0.01,0.05).(2)The level of serum folate,VitB12 in cerebral infarction were significantly lower than those in lacunar cerebral infarction(P0.05).Conclusion Folate and VitB12 could be a particular monitor factor for acute cerebral infarction and lacunar cerebral infarction disease,it is greatly helpful to distingui acute cerebral infarction and lacunar cerebral infarction clinically and also for prevention,therapy of ischemic cerebrovascular stroke disease. 　　Key words cerebral infarction lacunar cerebral infarction folate VitB12 homocyst(e)ine 　　随着我国人口的老龄化及生活模式的改变，脑梗死的发病率正逐年上升，并成为导致死亡及严重致残的主要疾病之一。由于目前在基层医院对已发生的缺血性脑血管疾病缺乏有效的根治手段，尤其是对已经引起严重神经系统后遗症的患者更是缺乏积极的治疗方法，故目前对脑梗死的治疗重点仍在对于引起其危险因素的监测、预防、治疗。除传统公认的缺血性脑血管病的危险因素如：高血压、高脂血症、糖尿病、吸烟、饮酒外，同型半胱氨酸作为脑血管疾病的独立危险因素近