湖北地区1999_2004年儿童感染病原菌分布与耐药性分析.pdfVIP

2008 18 3 # 425 # # # 1999- 2004 1 1 1 2 2 方 红 , 李秀云 , 王宏伟 , 孙自镛 , 杜鹏超 ( 1 2 , 430030) : , 1999- 2004 2004 6 15 , K-B , WHONET5 , ( NCCLS) 2002 , 6 , , 2 ; 94.0%, 50.0%; 74.0%, 16.5%; 2. 1%; 85. 1%98. 1%; , : ; ; : R378 : : 1005-4529(2008) 03-0425-03 Variation of Pediatric Clinical Bacterial Isolates andAntibiotic Resistance in Hubei Area F NG Hong, LI Xiu-yun, W NG Hong-wei, SUN Z-i yong, DU Peng-chao (Tongj i H osp ital, Tongj i Med ical College, H uaz hong University of Science and Technology , Wuhan, H ubei 430030, China) Abstract: OBJECTIVE To investigate the distribution of pediatric clinical bacterial isolates and the change in antibiotic resistance spectrum in Hubei area during 6 years. METHODS Data of bacterial susceptibility testing of clinical isolates from 15 tertiary hospitals in Hubei areafrom 1999 to 2004 were collected and analyzed by software WHONET-5. Results were assessed according to NCCLS 2002. RESU TS The amount of Gram-negative bacteria went down and of Gram-positive bacteriawent up during this period. The proportion of coagulase-negative Stap h ylococcus ( CNS) had been increasing and reached 32. 4% in 2004. T he proportions of Stap hylococcus aureus decreased from 15.7% in 1999 to 7. 4% in 2004. Escherichia were the second bacteria in the last two years. T he drug resistance rate of staphylococci against penicillin and erythromycin was more than 94% and 58%, respectively. The oxacillin resistance rate of CNS was 74%, significantly higher than that of