药用微乳处方因素对经皮吸收的影响.pdfVIP

Ch inese Jou rnal of N ew D rugs 2009 , 18 ( 7) ·综述 · 药用微乳处方因素对经皮吸收的影响 1 1, 2 , 3 2 3 开伟华 ,桂双英 ,彭代银 ,王 　均 ( 1 安徽中医学院药学院 ,合肥 23003 1; 2 安徽省 115现代中药产业创新团队 ,合肥 23003 1; 3 中国科技大学化学与材料科学院 ,合肥 23003 1) 　　[摘要 ] 　近年来微乳作为经皮吸收载体越来越受到重视 ,它能够增加亲脂性和亲水性药物的溶解性 , 促进药物的透皮吸收 。文中探讨微乳处方中药物 、油相 、表面活性剂 、助表面活性剂 、水相和促渗剂等对经皮 吸收的影响 , 旨在为采用微乳作为经皮吸收载体时的处方设计提供理论依据 。 [关键词 ] 　微乳 ;处方设计 ;经皮吸收 [中图分类号 ] R944 9　　[文献标识码 ] A 　　[文章编号 ] 1003 - 3734 (2009) 07 - 06 18 - 05 Effect of perform ula tion of m icroem ulsion on tran sderm a l ab sorption 1 1, 2 , 3 2 3 KA IW eihua , GU I Shuangying , PAN G D aiyin , WAN G Jun ( 1 D ep a rtm en t of P ha rm acy, A nhu i TCM , H ef ei 23003 1, Ch ina; 2 “115 ”Innova tive Team of A nhu i p rovince, H ef ei 23003 1; 3 Un ivers ity of S cience and Technology of Ch ina; H ef ei 230027) [ A b stract] 　M icroem u lsion ha s been frequen tly emp loyed over recen t years a s tran sderm al veh icle s. The m ain advan tage s of m icroem u lsion a s veh icle for drug delivery are their h igh so lub ilization cap acitie s for both hydro p h ilic and hydrop hob ic drugs. It can also enhance the cu taneou s ab sorp tion of the drugs. The influence of p harm a cy, o il p ha se, su rfactan t, co su rfactan t, water p ha se and p enetrating agen t in m icroem u lsion veh icle s on tran sderm al p erm eab ility is inve stigated to p rovide theory for p erform u lation of m icroem u lsion a s a derm al drug delivery. [ Key words] 　m icroem u lsion; p erform u lation; tran sderm al delivery ( 　　经皮吸收给药系统 Tran sderm al drug delivery