模拟移动床色谱(SMB)在生物分离中的应用.pdfVIP

CHAPTER 1 Simulated Moving Bed Chromatography (SMB) for Application in Bioseparation Sabine Imamoglu Aventis Pharma Deutschland GmbH, Industriepark Hoechst, 65926 Frankfurt, Germany. E-mail: sabine.imamoglu@ Simulated Moving Bed (SMB) technology is of rising interest in the field of bioseparation. This is particularly due to its advantages such as reduction of solvent consumption, high produc- tivity and final purities as well as low investment costs in comparison to eluent chromatogra- phy. SMB units can operate under high productivity overloaded conditions. This leads to non