《A randomized openlabel multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol》.pdfVIP

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《A randomized openlabel multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol》.pdf

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Journal of Geriatric Cardiology (2012) 9: 228−236 ©2012 JGC All rights reserved; Research Articles • Open Access • A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol 1 1 2 3 4 5 1 Xiao-Wei Ma , Xiao-Hui Guo , Xin-Hua Xiao , Li-Xin Guo , Xiao-Feng Lv , Quan-Min Li , Yan Gao 1 Department of Endocrinology, Peking University First Hospital, No.7 of Xishiku Street, Xicheng District, Beijing 100034, China 2Department of Endocrinology, Peking Union Medical College Hospital, No.1 Shuaifuyuan, Dongcheng District, Beijing 100005, China 3Department of Endocrinology, Peking Hospital, No.1 Dahua Road, Dongdan, Dongcheng District, Beijing 100730, China 4Department of Endocrinology, Military General Hospital of Peking PLA, No.5 Nanmencang, Dongsishitiao,Dongcheng District, Beijing 100070, China 5Department of Endocrinology, Second Artillery Forces General Hospital of Peking PLA, No.16 Xinjiekouwai Street, Xicheng District, Beijing 100088, China Abstract Objectives To evaluate the plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus (T2DM) and arteriosclerosis obliteran (ASO) when treated with Probucol plus Cilostazol in combination and individually. Methods In this open-label study, patients aged 40–75 years were randomized to receive conventional therapy alone, or with Cilostazol 100 mg bid, or with Probucol 250 mg bid, or with both in combination.