光合细菌防治高脂家兔动脉粥样硬化的研究.pdfVIP

412 Acta Nutrimenta Sinica,Oct.,2006, Vol.28 No.5 光合细菌防治高脂家兔动脉粥样硬化的研究 熊 琦 张肇铭 山西大学生命科学与技术学院光合细菌研究室 太原 030006 摘 要 目的 研究光合细菌对动脉粥样硬化的防治作用 方法 用高脂饲料建立实验性高脂家 兔模型 以螺旋藻作为阳性对照 设立空白对照 高脂对照 以肝脏总胆固醇含量(TC)主动脉斑块 面积百分比 PA及冠状动脉堵塞情况等为指标 观察光合细菌对动脉粥样硬化的防治作用 结果 光合细菌组的肝脏TC含量 肝系数 PA分别比高脂组降低了63.99%21.96%70.10%都具有非常 显著性差异 P 0.01同时也显著低于螺旋藻组 病理学检查表明 光合细菌组肝脏上的脂质沉积 和冠状动脉的病变也明显轻于高脂组和螺旋藻组 结论 光合细菌对高脂家兔的动脉粥样硬化具有很 好的防治作用 效果优于螺旋藻 [营养学报 2006285 412414] 关键词 光合细菌 高脂家兔 动脉粥样硬化 中图分类号 R151.41文献标识码 A 文章编号 0512-7955(2006)05-0412-03 PREVENTION AND TREATMENT OF PHOTOSYNTHETIC BACTERIAON IN EXPERIMENTAL HYPERLIPIDEMIC RABBITS XIONG Qi ZHANG Zhao-ming (PSB Research Laboratory,College of Life Science and Technology, Shanxi University Taiyuan 030006, China) Abstract Objective: To study the prevention and treatment of photosynthetic bacteria (PSB) on atherosclerosis (AS). Method: The hypolipidemic effect of PSB on atherosclerosis (AS) in rabbits induced by high cholesterol diet was studied with Spirulina platensis as positive control. The content of liver TC AS plaque area percentage (PA) and the emphraxis of coronary artery were determined. Results PSB could significantly reduce the content of TC in liver, the liver index (LW/BW), and PA 63.99%, 21.96%, 70.10%, respectively, and remarkably abate the lipid aggregation in liver and the pathological changes of coronary artery. In comparison PSB was better than Spirulina platensis. Conclusion PSB can prevent the formation of atherosclerosis in hyperlipidemic rabbits. [ACTA NUTRIMENTA SINICA, 2006, 28(5):412 414] Key words: photosynthet