《Are newborn ratderived neural stem cells more sensitive to lead neurotoxicity》.pdfVIP

NEURAL REGENERATION RESEARCH Volume 8, Issue 7, March 2013 doi:10.3969/j.issn.1673-5374.2013.07.001 [; ] Chan YH, Gao MY, Wu WT. Are newborn rat-derived neural stem cells more sensitive to lead neurotoxicity? Neural Regen Res. 2013;8(7): 581-592. Are newborn rat-derived neural stem cells more sensitive to lead neurotoxicity? *★△ 1 1, 2 1, 3, 4, 5 Yan Ho Chan , Mingyong Gao , Wutian Wu 1 Department of Anatomy, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong SAR, China 2 Department of Spine Surgery, Renmin Hospital of Wuhan University, Wuhan 430000, Hubei Province, China 3 State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China 4 Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China 5 GHM Institute of Central Nervous System Regeneration, Jinan University, Guangzhou 510630, Guangdong Province, China Abstract Lead ion (Pb2+) has been proven to be a neurotoxin due to its neurotoxicity on mammalian nervous Yan Ho Chan★, Master. system, especially for the developing brains of juveniles. However, many reported studies involved Corresponding author: 2+ the negative effects of Pb on adult neural cells of humans or other mammals, only few of which Wutian Wu, M.D., Ph.D., have examined the effects of Pb2+ on neural stem cells. The purpose of this study was to reveal the Professor, Department of