《Application of Nextgeneration Sequencing Technology in Forensic Science》.pdfVIP

Genomics Proteomics Bioinformatics 12 (2014) 190– 197 HO ST E D BY Genomics Proteomics Bioinformatics /locate/gpb REVIEW Application of Next-generation Sequencing Technology in Forensic Science Yaran Yang 1, Bingbing Xie 1,2, Jiangwei Yan 1,* 1 CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China 2 University of Chinese Academy of Sciences, Beijing 100049, China Received 1 July 2014; revised 28 August 2014; accepted 9 September 2014 Available online 14 October 2014 Handled by Andreas Keller KEYWORDS Abstract Next-generation sequencing (NGS) technology, with its high-throughput capacity and Forensics; low cost, has developed rapidly in recent years and become an important analytical tool for many Next-generation sequencing; genomics researchers. New opportunities in the research domain of the forensic studies emerge by Genomics; harnessing the power of NGS technology, which can be applied to simultaneously analyzing multi- Degradation of DNA ple loci of forensic interest in different genetic contexts, such as autosomes, mitochondrial and sex chromosomes. Furthermore, NGS technology can also have potential applications in many other aspects of research. These include DNA database construction, ancestry and phenotypic inference, monozygotic twin studies, body fluid and species identification, and forensic animal, plant and microbiological analyses. Here we review the appl