《Application of phage display technology in targeted therapy of breast cancer》.pdfVIP

Chinese-German J Clin Oncol May 2013, Vol. 12, No. 5, P246–P248 DOI 10.1007/s10330-013-1141-y Application of phage display technology in targeted therapy of breast cancer* 1, 2, 3 3 2 Mian Kong , Junye Wang , Baojiang Li 1 State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China 2 Department of Breast Surgery, The Central Hospital of Taian, Taian 271000, China 3 Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou 510060, China Received: 9 January 2013 / Revised: 7 February 2013 / Accepted: 20 March 2013 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2013 Abstract Phage display is a technology of gene expression and screening, it is widely used in the fields of defining antigen epitopes, signal transduction, genetic treatment, parasites research and tumor targeted therapy. Breast cancer is the most common cancer in women, we can obtain peptides specially associated with breast cancer by using phage display technology, and this method has great potential in early diagnosis of breast cancer and development new targeted drugs. Key words phage display; phage peptide library; peptides; breast neoplasms; targeted therapy Breast cancer is one of the most serious diseases that and phenotype in one phage particle, so we can get the threaten women’s life in the world. One report in 2011 encoding gene by screening the protein displayed outside showed that breast cancer was the first reason that caused of the phage. Based on the technology of phage display, women’s death in those who had cancer [1]. Except for the we