《Association between polycyclic aromatic hydrocarbons and human rectal tumor or liver cancer》.pdfVIP

Chinese-German Journal of Clinical Oncology July 2012, Vol. 11, No. 7, P391–P394 DOI 10.1007/s10330-012-0977-x Association between polycyclic aromatic hydrocarbons and human rectal tumor or liver cancer* 1 2 3 Guohong Jiang , Limin Lun , Liyuan Cong 1 Department of Clinical Laboratory, Qingdao Chest Hospital, Qingdao 266043, China 2 Department of Clinical Laboratory, The Affiliated Hospital of Medical College Qingdao University, Qingdao 266101, China 3 The Community Health Service Centers of Qingdao Tongan Road, Qingdao 266012, China Received: 20 February 2012 / Revised: 10 March 2012 / Accepted: 25 April 2012 © Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012 Abstract Objective: The aim of this study was to investigate the effect of polycyclic aromatic hydrocarbons (PAHs) in rectal carcinoma and hepatocarcinoma genesis. Methods: The PAHs in the human rectal cancer and liver cancer tissues, the adjacent tissues and homologous tissues without rectal cancer or liver cancer were extracted by ultrasonic wave. The extracts were then cleaned up and enriched by solid phase extraction, analyzed by high performance liquid chromatography (HPLC) with fluorescence spectroscopy. Results: Four kinds of PAHs were detected in human rectal and hepatic tissues. The contents of pyrene, 2-methylanthracene and benzo (a) pyrene in both rectal cancer tissues and adjacent homologous tissues were higher than rectal tissues without rectal cancer, the differences were statistically significant (P 0.05). The contents of phenanthrene in the three kind of tissue were not significant (P 0.05). The differences of the content of ea