ECF与DCF方案治疗晚期胃癌效果比较.docVIP

ECF与DCF方案治疗晚期胃癌效果比较 　　作者：陆网坤,蔡俊,马德,杨武,于立江,张铸　　作者单位：靖江市人民医院肿瘤内科，江苏 靖江 　　【摘要】 目的 比较ECF与DCF方案治疗晚期胃癌的近期疗效和不良反应。方法 将45例经病理检查确诊的晚期胃癌病人分为2组。 ECF组21例，给予表阿霉素60 mg/m2静脉注射,第1天;顺铂75 mg/m2分3～4 d静脉滴注;氟尿嘧啶每天500 mg/m2持续输注96 h。DCF组24例，给予多烯紫杉醇75 mg/m2静脉滴注2 h，第1天;顺铂与氟尿嘧啶用法同ECF组。每3周为1个周期，2～3个周期评价疗效，对两组缓解率、生活质量改善率及不良反应进行比较。结果 ECF组与DCF组的缓解率分别为56.2%和58.3%，两组差异无显著性(P0.05);两组神经系统毒性反应有明显差异(P=0.001)。结论 ECF和DCF方案对晚期胃癌病人近期疗效均较好,不良反应可以耐受,生活质量明显提高。 　　【关键词】 胃癌 　　A COMPARISON BETWEEN ECF AND DCF THERAPEUTIC REGIMEN IN THE TREATMENT OF ADVANCED GASTRIC CARCINOMALU WANG-KUN, CAI JUN, MA DE, et al(The Peoples Hospital of Jingjiang, Jingjiang 214500, China) [ABSTRACT]ObjectiveTo compare the efficacy and toxicity between ECF regimen (epirubicin+Cisplatin+5-FU) and DCF regimen (docetaxel+Cisplatin+5-FU) for advanced gastric carcinoma. MethodsForty-five cases of advanced gastric carcinoma were divided into two groups. ECF group consisted of 21 patients who received epirubicin 60 mg/m2 iv injection on the first day. DCF group consisted of 24 patients receiving 96 h iv drip of 75 mg/m2 docetaxel on the first day. Both groups were given iv drip of 75 mg/m2 Cisplatin and 500 mg/m2 5-FU within 3-4 days. Both regimens were repeated every three weeks. After 2-3 cycles of treatment, the remission rate, quality of life and side effects were compared. ResultsThe overall remission rates of the ECF group and DCF group were 56.2% and 58.3%, respectively (P0.05). But there were significant differences in peripheral neuropathy between the two groups (P=0.001). ConclusionBoth ECF and DCF regimens showed a good short-term effect for advanced gastric carcinoma, the side effects are accepted, the quality of life improved. [KEY WORDS]Stomach neoplasms; Antineoplastic combined chemotherapy protocols; Program evaluation 　　胃癌一直是世界性的健康问题,是世界第四大常见恶性肿瘤和第二大癌症死亡原因[1]。许多病人诊断时已属晚期,可以行根治性手术切除的病人60%也会局部复发或远处转移。联合化疗是晚期胃癌的主要治疗方法。自2004年1月起，我们采用表阿霉素、顺铂、 氟尿嘧啶组成的ECF方案与多烯紫杉醇、顺铂、氟尿嘧啶组成DCF方案治疗晚期胃癌45例,疗效较好,现报告如下。 　　1 资料与方法