三阶导数光谱法测定肤宁乳膏中硝酸益康唑的含量.pdf

三阶导数光谱法测定肤宁乳膏中硝酸益康唑的含量 曹 健 , 张 倩, 黄林清( 第三军医大学新桥医院药剂科, 重庆市 4 0003 7) R927 2 A 100 1- 0408(2006) 13- 1009- 03 目的: 建立以三阶导数光谱法测定肤宁乳膏中硝酸益康唑含量的方法方法: 在231nm 波长处测定硝酸益康唑的三阶导 数光谱 幅值结果: 硝酸益康唑的检测浓度线性范围为 1224~ 28 56g/ ml( r = 10 000) , 平均回收率为100 4% ( RSD= 088%) 结论: 本方法简便易行重现性好, 适合该制剂的质量控制 三阶导数光谱法;肤宁乳膏; 硝酸益康唑; 含量 Determination of Econazole Nitrate in Funing Ointment by Third Order Derivative Spectrometry CAO Jian, ZHANG Qian, HU ANG Linqing( Deptof Pharmacy, Xinqiao Hospital, T he T hird M ilitary M edi cal U niversit , Chon in 400037, China) y gq g ABST ACT OBJECT IVE : To determine econazole nitrate in Funin ointm ent b third order derivative s ectromet r g y p y METH ODS: T he third order derivat ive s ectra vibration am litude of econazole nit rat e was determined at a w avelen th of p p g 231nm RES ULTS: T he linear range of the econazole nitrate w as 12 24~ 2856 g/ ml( r = 1000) , t he average recovery w as 1004% ( RSD= 088%) CONCLUSIONS: T he m ethod is simple and reproducible, and suitable for the quality cont rol of Fun_ in ointment g KEY WO DS T hird order derivative s ect rometr ; Funin ointment ; Econazole nitrate; Content p y g 2 EPS 32 Tab 2 Percenta es of EPS induced b different route of EPS , g y administration ( 1 688 , 74 52%) , ( 1 626 , 96 32%) , , ( n) ( %) ( n) ( %) ( n) ( %) , , 1 11 8731 32 7688 37 1326 ( 39 7 , 17 53%) , 90 70 83 1199 219 7849 - D2 , 039 4 780 31 243 1 014 1 036 EPS 8 063