叶黄素对顺铂所致大鼠急性肝损伤的防治作用.pdfVIP

2011; 27( 2) 51 left anter ior descend ing branch of co ronary artery for 10m in and remov ing the ligation later to reperfuse for 10m in in v ivo. W e observed the in- cidence of arrhy thm ias and arrhythm ia scores, w e m easured m yo ca rdia l in jury sizes and m yo ca rdia l infa rct sizes(M S) by dy ing inury ventr-i cles of -R rat in TTC so lution, and measured the leve l of serum latic dehydrogenase( LDH ), m yocard ia l supero side d ism utase( SOD) , m yo- cardia lm alond ia ldehyde( MDA ) through UV - Spectrom eter. Com pared w ith the -R to explore its problem m echan ism. R esu lts : A pigen in ( 4 mg /kg) can suppress the inc idence of arrhy thm ias, reduce a rrhy thm ia scores( P 0. 05); A pig en in( 2m g/kg, 4 mg /kg ) can rem arkably decreased the con tent ofm yocard ialM DA ( P 0. 01); A pigen in ( 2mg /kg4 mg /kg ) can mi proved m yocard ia l SOD activ ity ( P 0. 05); A p igenin ( 1m g/kg2 mg/ kg4 m g/kg) can s ignificantly reduce the leve l of serum LDH ( P 0. 0 1); A p igenin ( 1m g/kg2 m g/kg4 mg /kg ) can shorten m yo ca rdia lM S ( P 0. 01) . Conclusion: A pig en in can decrease the conten ts ofm yocard ia lM DA and serum LDH, sho rten m yo- cardia lM S, and increase m yocard ia l SOD activ ity. A pig en in can prevent myocardia l -R arrhythm ia. T he refo re, apig en in plays a protec tive ro le on myocardial ischem ia reper fusion in jury. K ey w ord s ap igen in; ischem ia reperfusion; latic dehydrogenase; supe roside d ismu tase; m alond ia ldehyde; arrhythm ia; infarct s ize * 李文甫, 张慧珠 , 张文丽, 刘淑梅, 张博男, 韩淑英 ( 河北联合大学医学部, 唐山 063000) : 观察叶黄素( LU) 对顺铂( CP) 诱导的大鼠急性肝损伤的保护作用: 将 30 只 SD 大鼠随机分为 5 组, 分 别为对照组顺铂组 同剂量叶黄素( 10m g/kg20mg /kg 和 40m g/kg) + 顺铂组大鼠连