姜黄素与辛伐他汀降血脂及抗氧化作用比较.pdfVIP

! 204 ! 2010 30 3 Chin Hosp Pharm J, 2010 Feb, Vol 30, No. 03 , : , , [ 1] , , . [J] . , 2002, 33. ( 5): 475476. [2] . [J] . , 2006, 2: 5053. [2] [] , , (20~ 40 ) , 1 1 2 ( 1. , 0630 00 ;2 . , 姚国贤,傅静波, 韩刚 0 63 00 0) [ ] : 以高脂血症大鼠为模型比较姜黄素姜黄素固体分散体辛伐他汀 血脂及抗氧化作用: 雄性 SD 大鼠 灌胃给予高脂肪乳剂制备高脂血症大鼠模型造模的同时,给予姜黄素姜黄素固体分散体辛伐他汀, 连续给药6 周后测定 总胆固醇(TC) 甘油三酯( TG) 高密度脂蛋白胆固醇( HDLC) 低密度脂蛋白胆固醇( LDLC) 丙二醛( MD ) 的含量, 超氧 化物歧化酶(SOD) 的活性: 姜黄素与姜黄素固体分散体在 低血清中甘油三酯( T G) 的作用明显优于辛伐他汀( P 0 .0 5) ; 而辛伐他汀 低血清中总胆固醇的作用明显优于姜黄素(P 0.0 1) ;姜黄素与姜黄素固体分散体能提高血清及肝匀浆 中SOD 活性, 低MD 含量,姜黄素抗氧化作用明显优于辛伐他汀( P 0 .0 1) ;姜黄素固体分散体的 血脂及抗氧化能力明 显优于姜黄素(P 0 .0 1) :姜黄素固体分散体对高脂血症模型大鼠具有 低血脂及抗氧化的双重作用 [ ] 姜黄素; 固体分散体; 辛伐他汀; 高脂血症; 抗氧化 [ ] R969 [ ] [ ] 100152 13( 2010) Comparativestudyontheantihyperlipidemicandantioxidativeeffectsof curcuminandsimvasta tin 1 1 2 Y O Guoxian , FU Jingbo , H N Gang ( 1. Department of Pharmacy, Fengrun People s Hospital, Hebei Tangs han 06300 0, China; 2. Pharmaceutical Department of North China Coal Medical University,Hebei Tangshan 0 63 00 0, China) ABSTRACT:OBJECTIVE To compare the antihyperlipidemic and antioxidative effect of curcumin, curcumin solid dispersion and simvastatin. ETHODS Hyperlipidemic model were induced by feeding a high lipidic diet in Sprague Dawley rats. The model rats were given curcumin, curcumin solid dispersion and simvastatin for 6 weeks then the concentration of cholesterol ( TC) , triglyceride( TG) , high density lipoproteincholesterol(HDLC) , low density lipoproteincholesterol(LDLC) ,