短帚霉对小鼠致病性的实验研究_万力.pdfVIP

658 2008 11 22 11 Ch in J Derm Ven ereol, N ov. 2008, Vol. 22, No. 11 短帚霉对小鼠致病性的实验研究 万力, 张国强, 汪贵娥, 朱海军 [ ] 研究短帚霉的致病性, 探讨系统性真菌病的发病机制 给不 免疫状态的小鼠经皮下腹 腔静脉途径注射短帚霉菌悬液, 对处死及自然死亡小鼠各脏器进行组织病理检查和逆培养, 观察小鼠生存率 正 常皮下组和免疫抑制皮下组仅在接种部位出现脓肿, 不引起播散性损害; 不 免疫状态的腹腔组和静脉组小鼠早期就出 现各脏器的播散感染组织病理学和逆培养均阳性免疫抑制组小鼠有自然死亡 短帚霉是 一种毒性较强的条 件致病菌 [] 短帚霉; 真菌病; 动物实验; 组织逆培养; 组织病理学 [] R 379 [] A [] 1001- 7089( 2008) 11- 0658- 04 AnimalExperimental Study on Pathogenicity of Scopulariopsis Brevicaulis WAN Li, ZHANG Guo-q ian , WANG Gu-i e, et al (Dermatology of D ep artment, theFourthAff iliatedH osp ital of H ebeiM ed ical University, Shijiazhuang 050011, hina) Abstract: Objective T o investi ate the patho en icity of Scopulariops is brevicau lis and to discuss the patho enes is of sy s- tem icm ycosis. M ethods T o inject the suspens ion in them ice of the d ifferent mi m une status by subcutaneous, intraperitoneal, in- travenous injection m eans, undertake the patholo ical exam ination and inverse train in of the or ans of sacrificed and d ied of natu- ral m ice, and observe the natural survival tmi e. Results The inoculated positions appeared abscesses in the subcu taneous roup of normal and mi munocomprom ised m ice, but didnt cause spread in dam a e. The intraperitoneal and intravenousm ice of the d iffer- ent mi mune status soon appeaed the or ans infection. H istopatholo y and inverse cu lture w ere positive. Imm unosuppressed m ice had died of natural causes. onclusion Scopulariopsis brevicau lis is a kind of opportun istic fun usw ith relatively h i h viru lence. Keywords: Scopulariopsis brevicaulis; fun al diseases; anmi al expermi ents; or an izations inverse culture; h istopatholo y , 6 7 3. 0 10 ~ 1. 0 10 /mL , ,