炎性因子与胰岛素抵抗的研究进展_阮丹杰.pdfVIP

# 508# 2009 2 15 4 M dicalR cap itulat , F b 2009, Vo.l 15, No. 4 阮丹杰, 王 伟 (, 101400) : R587 : A : 1006-2084 ( 2009) 04-0508-04 : 胰岛素抵抗在 2型糖尿病代谢综合征等肥胖相关性疾病中起到十分重要的作 胰岛 3 素抵抗是一个低度炎症状态, 大量由免疫细胞和脂肪细胞分泌的炎性介质参与了胰岛素抵抗的发 [ 4] Sh in 生发展, 其中包括肿瘤坏死因子 A白细胞介素 6 和一些脂肪因子而且, 抑制物激酶( IKK ) /NF-Jƒ [ 5] C 通路c- jun氨基末端激酶通路以及细胞因子信号抑制物 3 通路也参与了此过程它们相互作 共同 促进了胰岛素抵抗发生发展, 并为胰岛素相关性疾病的防治提供又 一个新的靶点 A : 炎症; 炎性因子; 胰岛素抵抗; 代谢综合征 ( tumor n crosis factor-alpha, Recent Progress on Inflammatory Cytokine and Insulin Resistance RUAN Dan-j ie, WANG Wei. TNF-A) (Department of Endocrinology, the First osp ital of uairou D istrict, Beij ing 101400, China) , , Abstract: Insulin r sistanc ( IR) plays a k y rol in th pathophysiology of ob sity-r lat d dis as s such as typ 2 diab t s and m tabolic syndrom . It has b n d m onstrat d that IR is associat d w ith a stat of chron ic low-grad inflamm ation, and s v ralm diators of inflamm ation r l as d from variou s c ll typ s, in clu- ding mi m un c lls and adipocyt s, h av b n id ntifi d as b ing involv d in th d v lopm nt of IR. Am ong , thos ar s v ral pro- inflamm atory cytok in s such as tum or n crosis factor-A( TNF-A) , int rl uk in-6 ( IL-6) , and variou s adipo-cytok in s. Furth rmor , s v ral transcription factors and k inas s su ch as inh ib itor of kappa B k inas-B ( IKKB ) /nu cl ar factor-JB( NF-JB), c-Jun N-t rm inal k inas ( JNK) , and suppr ssor of cytok in signalling-3 ( SOCS-3) p articipat in th is proc ss. A s a compl x n twork of inflamm atory cytok in s, adipo-cy- 2 tok in s, and tran scription factors ar involv d