山东地区根除幽门螺杆菌对胃癌发生变化趋势的研究.pdfVIP

Chinese Journal of Digestive Diseases 2005; 6; 114– 115 The Chinese Journal of Digestive Diseasesxxx 2005L ZhouIncidence of gastric cancer after203Blackwell Publishing, Ltd.CDDOxford, UKOriginal Article61443-961105 Chinese Medical Association Shanghai Branch et al. H. pylori eradication The changing trends of the incidence of gastric cancer after Helicobacter pylori eradication in Shandong area Li Ya ZHOU, San Ren LIN, Shi Gang DING, Xue Biao HUANG, Li ZHANG, Ling Mei MENG, Rong Li CUI Jin ZHU Department of Gastroenterology, Third Hospital of Beijing University, Beijing, China INTRODUCTION 1000 mg, bid) for 1 week, and the placebo group served as control. One month after completion of ther- Gastric cancer remains one of the leading types of apy, H. pylori status was reassessed by 13C-urea breath cancer worldwide and primary prevention is of critical test. Follow-up studies were carried out in the 2nd, 5th, importance, especially in high-risk areas where Helico- and 8th year, respectively. bacter pylori infection has been shown to be respons- ible for approximately 50% of cases. Although many The eradication rate of H. pylori in the treatment group studies have found an association between H. pylori was 89%, so 246 patients became H. pylori negative infection and development of gastric cancer, many and 306 patients remained H. pylori positive (includ- aspects of this relation remain uncertain.1,2 The pur- ing 276 patients in the placebo group). At the 5th year, po