494例药物性肝病的临床调查与分析.pdf

494 ClinicalMedicalJournalofChina，2004．V01．11，No．4中国临库压学 2004年8月第11卷第4期 ■论著■ 494例药物性肝病的临床调查与分析 周世明 贾 杰(海南省人民医院感染科，海口 570311) 摘要 目的：分析总结近年来药物性肝病的情况，提高本病的诊断治疗水平。方法：回顾调查1994～2004年各种药物致药物 性肝病494例，分析统计每年发病例数的变迁及l临床情况。结果：抗结核药、中草药、抗生素、抗肿瘤药、抗甲亢药是主要的损 功能。 关键词 药物性肝病损肝药物 and of LiverDiseasein494cases ClinicalInvestiation AnalysisDrug--induced Zhou Provincial 570311) Jie(Hainan Hospital，Haikou Shiming，Jia People’S Abstract of and levelon and state liverdisease theclinical Objective：Toanalyse drug—induced promote diagnosistherapy． and 1994 494 causes，incidenceof liver to2003 cases．Re— Methods：Investigate changesdrug—inducedduring byInvestgated suits：Antituberculosis，traditionalChinesemedicines，antibiotics，anti—canaerwerethemostcorn— drugs，Antithyroiddrugs mon for liverdisease．Theincidenceofinduced—liverdisease wasincreaed．ThetimeOf drugsdrug—induced annually drug— inducedliverdisease was63．52 incideneehad61．34％inthefirstmonthand70．24％inthesrcondmonth． average days．The The had54．86％andNOtwas45．14％in494cases．Thetotaleffectwas93．18％on{iftertreatment． symptomticpatients attentionto liverdiseaseand monitorliver Conclusion：Shoulddrug—induced duringdrugs function． treatment．physicians Words liverdisease liver Key Drug—induced Injurydurgs 近年来，临床上药物性肝病经常发生，约占药物 月经过多、痛风、囊虫病、阳萎、腰肌劳损等52例