Tiam1和Rac1在宫颈鳞癌组织中的表达及临床病理意义.pdf

·282· 冯天平，赵景志，庞超，张凌云，尹磊 (河南省军区医院，河南郑州450003) 摘要：目的 探讨T淋巴瘤侵袭转移诱导因子1(Tiaml)及Rac 移的关系。方法 aml的蛋白表达呈正相关关系(r=0．328，P0．05)。结论 及Tiaml的蛋白表达有望成为宫颈鳞癌早期诊断和判断预后的分子指标。 关键词：T淋巴瘤侵袭转移诱导因子1；RacGTP酶激活蛋白l；宫颈鳞癌；免疫组化；浸润转移 中图分类号：R737．33文献标识码：A 文章编号：1673—5412(20lO)04—0282—04 TheClinical ofthe of PathologicalSignificanceExpressions Tiam1 andRaclProteinin Cell theCervix Carcinomaof Squamous Lei FengTianping，ZhaoJingzhi，PangChao，ZhangLingyun，Yin in (TheMilitaryRegionHospitalHe’nan，Zhengzhou450003。China) To the ofthe ofT invasionandmetastasisfactor Rac Abstract：Objective 1(Tiaml)andGT- explorerelationshipexpressionslymphoma Pase andthe andmetastasisin cellcarcinomaofthecer- activatingprotein1(Racl)proteinoccurrence，development。invasionsquamous vix．MethodsS-Pimmunohistochemicalmethodwasusedtodetectthe ofRaclandTiaml in46cases cell expressions protein squamous ofthe cases carcinomacervix，21cervical and26casesofnormalcervical The rates intraepithelialneoplasia epithelium．Resultsexpression ofTiamI decreasedturnsin andnormalcervical 56．5％ protein by carcinoma。cervical intraepithelialneoplasia epitheliumspecimens。were a differencein (26／46)，28．6％(6／21)，7．7％