辐射防护与辐射治疗剂临床应用及进展.pdfVIP

药学进展 辐射防护与辐射治疗剂临床应用及进展 1，3 2 1 2 （1 北京大学第三医院药剂科，北京，100191；2 北京大学第三医院肿瘤化疗与放射病科，北京， 易湛苗 ，张照辉 ，翟所迪 ，贾廷珍 100191；3 北京大学药学院，北京，100191） 摘要 目的：探讨辐射防护与辐射治疗剂的临床应用及进展。方法：通过查阅最新的研究文献，对辐射防护与辐射治疗剂的临 床应用及进展进行归纳、综述。结果：辐射防护与辐射治疗剂有：氨磷汀、蛋白酶抑制剂、激素类抗放射药、天然药物、细胞因子 和间充质干细胞等；其中，细胞因子和间充质干细胞作为辐射防护与辐射治疗剂的研究在国内外备受关注。结论：辐射防护与 辐射治疗剂的临床应用有了新的进展，为核事故临床救治提供了新的治疗依据。 关键词 辐射防护剂；辐射治疗剂；辐射损伤 中图分类号：R979.6 文献标识码：A 文章编号：1672 - 8157 （2009）04 - 0239 - 04 Clinical Application and Advance of Radiation Protection and Radiation Treatment Agents 1,3 2 1 2 (1 Department of Pharmacy, Peking University Third Hospital, Bei - YI Zhan-miao , ZHANG Zhao-hui , ZHAI Suo-di , JIA Ting-zhen jing, 100191 ; 2 Department of Radiation Sickness and Chemotherapy, Peking University Third Hospital, Beijing, 100191; 3 Peking University School of Pharmaceutical Sciences, Beijing, 100191) ABSTRACT Objective: To investigate the clinical applications and the advance of radiation protection and radiation treatment agents. Methods: Clinical applications and the advance of radiation protection and radiation treatment agents were summarized by reviewing the latest literatures. Results: Radiation protection and radiation treatment agents included amifostine, protease inhibitor, hormone, traditional Chinese medicine, cytokines, mesenchymal cell, etc. Cytokines and mesenchymal cell were concerned in radiant areas. Conclusion: There is a new progress in the clinical application of radiation protection and the treatment agents, which will provide the new basis for clinical treatment of a nuclear accident. KEY WORDS Radiation protection agents; Radiation treatment agents; Radiation injury 随着核工业的迅速发展与核技术的广泛应用，人