An Analysis of a Circadian Model Using The SmallGain Approach to Monotone Systems.pdfVIP

3 An Analysis of a Circadian Model Using The 0 0 Small-Gain Approach to Monotone Systems 2 c e David Angeli D Dip. Sistemi e Informatica 2 University of Florence, 50139 Firenze, Italy angeli@dsi.unifi.it ] C Eduardo D. Sontag∗ O Dept. of Mathematics . h Rutgers University, NJ, USA t a sontag@hilbert.rutgers.edu m [ 1 Abstract v 2 In this note, we show how certain properties of Goldbeter’s 1995 model 6 for circadian oscillations can be proved mathematically, using techniques 0 from the recently developed theory of monotone systems with inputs and 2 outputs. The theory establishes global asymptotic stability, and in partic- 1 ular no oscillations, if the rate of transcription is somewhat smaller than 3 that assumed by Goldbeter. This stability persists even under arbitrary 0 delays in the feedback loop. / h t a 1 Introduction m : v The molecular biology underlying the circadian rhythm in Drosophila is the i focus of a large amount of both experimental and theoretical work. Goldbeter X proposed a simple model for circadian oscillations in [4] (see also his book [5]). r a Although by now several more realistic models are available,