启注时刻对进入分支动脉药液灌注率影响的模拟实验研究.pdfVIP

______________________________________________________________________________ ∗ 启注时刻对进入分支动脉药液灌注率影响的模拟实验研究 董兵超 邱霖 周旭欣 袁支润 （四川大学生物力学研究室，成都 610065 ） 摘要：使高浓度的治癌药液经分支动脉进入癌发病区直接高效杀死癌细胞而又不损伤正常细胞是广大医学工作者多年追求的 目标。本文用体外模拟实验的方法，研究了推注时相对进入支气管动脉的药液灌注率的影响，并与数值模拟结果进行了比较， 获得了最佳灌注率的启注时刻趋势与数值模拟结果相同的结论。为临床血管性介入治疗中减少药液耗损、降低对其它区域正 常细胞的损害，提供了一种有效的药物灌注方法。 关键词：支气管动脉；肺癌介入治疗；脉动注射；启注时刻；推注持续时间；药液灌注率 中图分类号：O357.1 文献标识码：A Simulation Study for effects of Time phase of Drug Injection on Drug Perfusion Ratio into Branch Artery Dong Bingchao Qiu Lin Zhou Xuxin Yuan Zhirun (Biomechanics Institute, Si Chuan University, Chengdu 610065) Abstract A simulation system of interventional treatment of lung cancer was established. Relation between drug perfusion ratio into branch artery and the starting time of drug injection in a cardiac circle was studied when liquid drug was injected into Aorta intermittently. Numerical simulation of two-dimension experimental model was also given. The results show that the drug perfusion ratio into branch artery varies with time phase of drug injection, i.e. the starting time of drug injection. They also provide foundation for those who seek to optimize the clinical interventional treatment of lung cancer. Key words branch artery; interventional treatment of lung cancer; time phase of drug injection; pulsant injection; starting time of drug injection; duration of drug injection; drug perfusion ratio 1. 引言 血管性肺癌介入治疗动脉灌注主要有支气管动脉灌注（BAI）和肺动脉灌注(PAI)两种。传统的动脉灌 注是 BAI，它采用 Seldinger 法[1]，但该治疗方法易引起一些并发症 [2][3] ，严重者会引起脊髓损伤，甚至会 导致高位截瘫[4]。如何使高浓度的抗癌药物经分支动脉直接进入癌发病区而又不引起相应的并发症，是血 管性介入治疗研究的热点之一。1993 年，岑人经、贺继刚等人对肺癌支气管动脉介入治疗进行了研究，提 出了“自然灌注区”的概念，袁华等又对此做了深入研究[5]。为获得最佳的药液灌注效