探讨鼻分泌物嗜酸细胞检测在变应性鼻炎舌下免疫治疗前后变化.pdfVIP

doi：10．3969／j．issn．1007—4856．2012．01．006 探讨鼻分泌物嗜酸细胞检测在变应性鼻炎舌下免疫 治疗前后变化 苏芳1孟庆翔1谢景华1王磊1 【摘要】目的观察过敏性鼻炎患者舌下含服粉尘螨滴剂治疗前后鼻分泌物嗜酸粒细胞数量的变化。方法43例过敏性鼻 炎患者，行粉尘螨滴剂舌下含服免疫治疗。分别在治疗前及治疗后第2周、4周及8周采集鼻分泌物涂片，计数鼻分泌物中的嗜酸 性粒细胞，比较分析治疗前后的数值变化。结果与治疗前相比较，免疫治疗后第4周与第8周时，鼻分泌物嗜酸性粒细胞数下 结论舌下含服粉尘螨滴剂治疗的第4周开始，过敏性鼻炎患者鼻黏膜局部免疫状态开始发生改变。 【关键词】变应性鼻炎；嗜酸性粒细胞；免疫治疗l螨 ofEOSnumberinnasalsecretion Changes followingsublingualspecific rhinitis immunotherapyamongpatients而thallergic SU Lei Fang,MENG口ingxiang,XIEJinghua,9AN6 TheFirst of MunicipalHospital To the of innasal．僦reiion [Abstractl eosinophils(EOS)numberfollowingsublingualspecific Objectiveinvestigatechanges fromdustmites with rhinitisbasedonaclinicaltrial．Methods withthe extractmade immunotherapyantigen amongpatientallergic in Includedinthis were43caseswith flfinitistreatedwith EOSnumbernasal study allergic sublingualspecificimmunotherapy．Their sectionswasddcectedbeforetheu说tmentandatthe and8thweeks the correlationofEOSnumber 2nd,4th followingtherapy．Then,the When the withthe cour3ewas ina madebeforeand the with way therapeutic analyzedcomparative duringtherapy．Resultscompared data before innasalsecretionwasshown todecreaseatthe4thweekand tilltothe8th obtained number mmtment,EOS beginning