《Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model》.pdfVIP

NEURAL REGENERATION RESEARCH February 2015,Volume 10,Issue 2 RESEARCH ARTICLE Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model 1 1 2, * 3 4 1 Ibrahim Erkutlu , Mehmet Alptekin , Sirma Geyik , Abidin Murat Geyik , Inan Gezgin , Abdulvahap Gök 1 Department of Neurosurgery, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey 2 Department of Neurology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey 3 Department of Neurosurgery, Sanko University, Gaziantep, Turkey 4 Department of Neurosurgery, Private Park Hospital, Adıyaman, Turkey Abstract *Correspondence to: Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potas- Sirma Geyik, M.D., sium is common in developing countries. It has been shown that cyclosporin A, a powerful drsirmageyik@. immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug in- doi: 10.4103/1673-5374.152381 jection injury. This study aimed to assess the time-dependent efficacy of cyclosporine-A as an / immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the Accepted: 2014-11-22 length