《Effect of Hypertonic Versus Isotonic Saline Resuscitation on Heme Oxygenase1 Expression in Visceral Organs Following Hemorrhagic Shock in Rats》.pdfVIP

684 Biomed Environ Sci, 2013; 26(8): 684-688 Letter to the Editor Effect of Hypertonic Versus Isotonic Saline Resuscitation on Heme Oxygenase-1 Expression in Visceral Organs Following Hemorrhagic Shock in Rats* 1,# 2 1 2 LU Yuan Qiang , GU Lin Hui , JIANG Jiu Kun , and MOU Han Zhou To compare the early effects of hypertonic and expression of HO-1 has also been shown in isotonic saline resuscitation on heme oxygenase-1 numerous pathophysiological states (e.g., trauma, (HO-1) expression in organs of rats with sepsis, pancreatitis and ischemia-reperfusion hemorrhagic shock. Rats were randomly divided injuries). Over-expression of HO-1 is cytoprotective into hypertonic saline resuscitation (HTS), normal and immunoregulatory in a variety of tissues[8-10]. saline resuscitation (NS) and sham groups. HO-1 In our previous study, small-volume mRNA, protein expression and apoptosis were resuscitation with HTS was more effective than evaluated in organs. In the HTS group, significant isotonic saline resuscitation in reducing initial difference was noted in HO-1 protein in small apoptosis in the small intestinal mucosa in a rat HS intestinal mucosa and liver compared with the NS model[4]. Therefore, we hypothesized that and sham groups, and in HO-1 mRNA in liver and resuscitation