《Effect of Phenylephrine on Alveolar Fluid Clearance in Ventilatorinduced Lung Injury》.pdfVIP

Chin Med Sci J Vol. 28, No. 1 March 2013 P. 1-6 CHINESE MEDICAL SCIENCES JOURNAL ORIGINAL ARTICLE Effect of Phenylephrine on Alveolar Fluid Clearance in Ventilator-induced Lung Injury△ 1 2 3 1 2 1 Nai-jing Li *, Xiu Gu , Wei Li , Yan Li , Sheng-qi Li , and Ping He 1Department of Gerontology, 2 Department of Respiratory, Shengjing Hospital, China Medical University, Shenyang 110004, China 3College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110004, China Key words: α-adrenergic agonist; pulmonary edema; alveolar epithelium Objective To investigate the effect of phenylephrine (an α-adrenergic agonist) on alveolar fluid clearance (AFC) in ventilator-induced lung injury and the possible mechanism involved. Methods A total of 170 male Wistar rats were randomly allocated into 17 groups (n=10) using ran- dom number tables. Short-term (40 minutes) mechanical ventilation with high tidal volume (HVT) was per- formed to induce lung injury, impair active Na+ transport and lung liquid clearance in the rats. Unventilated rats served as controls. To demonstrate the effect of phenylephrine on AFC, phenylephrine at different con- -5 -6 -7 -8 -9