《Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease》.pdfVIP

NEURAL REGENERATION RESEARCH March 2014,Volume 9,Issue 6 Heat shock protein 90 is a potential therapeutic target for ameliorating skeletal muscle abnormalities in Parkinson’s disease 1 2 3 Nour Erekat , Ahed Al-Khatib , Muhammed Al-Jarrah 1 Department of Anatomy, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan 2 Department of Pathology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan 3 Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan (Current address: Fatima College of Health Sciences (FCHS). Abu Dhabi, UAE) Abstract Corresponding author: Previous studies have confirmed that heat shock protein 90 overexpression can lead to dopami- Muhammed Al-Jarrah, Ph.D., P.T., Depart- nergic neuronal death. This study was designed to further investigate what effects are produced ment of Rehabilitation Sciences, Faculty of by heat shock protein 90 after endurance exercise training. Immunohistochemistry results Applied Medical sciences, Jordan University showed that exercise training significantly inhibited heat shock protein 90 overexpression in the of Science and Technology, 22110 P.O. box soleus and gastrocnemius in Parkinson’s disease rats, which is a potential therapeutic target for 3030. Irbid, Jordan, jarrahm@.jo. ameliorating skeletal muscle abnormalities in Parkinson’s disease. doi:10.4103/1673-5374.130105 Key Words: nerve regeneration; heat shock protein 90; Parkinson’s disease; exerecise; soleus muscle; / gastrocnemius muscle; skeletal muscle; treadmill excise; neural regeneration Accepted: 2014-01-01 Funding: This study was finan