《Heavy ion and Xray irradiation alter the cytoskeleton and cytomechanics of cortical neurons》.pdfVIP

NEURAL REGENERATION RESEARCH June 2014,Volume 9,Issue 11 Heavy ion and X-ray irradiation alter the cytoskeleton and cytomechanics of cortical neurons 1, 2 2, 1 1 1 3 4 2, 1 3 5 Yuting Du , Jie Zhang , Qian Zheng , Mingxin Li , Yang Liu , Baoping Zhang , Bin Liu , Hong Zhang , Guoying Miao 1 School of Stomatology, Lanzhou University, Lanzhou, Gansu Province, China 2 School of Nuclear Science and Technology, Lanzhou University, Lanzhou, Gansu Province, China 3 Department of Radiation Biology and Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu Province, China 4 School of Civil Engineering and Mechanics, Lanzhou University, Lanzhou, Gansu Province, China 5 Gansu Provincial Hospital, Lanzhou, Gansu Province, China Abstract Yuting Du and Jie Zhang equally Heavy ion beams with high linear energy transfer exhibit more beneficial physical and biological contributed to this work. performance than conventional X-rays, thus improving the potential of this type of radiotherapy in the treatment of cancer. However, these two radiotherapy modalities both cause inevitable Corresponding author: brain injury. The objective of this study was to evaluate the effects of heavy ion and X-ray irra- Bin Liu, Ph.D., School of Nuclear Science diation on the cytoskeleton and cytomechanical properties of rat cortical neurons, as well as to and Technology, Lanzhou University, determine the potential mechanism of neuronal injury after irradiation. Cortical neurons from Lanzhou 730000, Gansu Province, China; 30 new-born mice were irradiated with heavy ion beams at a sing