《How do corticosteroids influence myelin genesis in the central nervous system》.pdfVIP

NEURAL REGENERATION RESEARCH May 2014,Volume 9,Issue 9 PERSPECTIVES inhibitory influence of myelin (Huang et al., 2005). In myelin mu- How do corticosteroids influence tants lacking compact myelin, axons display increased slow axonal transport, as well as abnormalities in cytoskeletal components, and myelin genesis in the central nervous metabolic function (Brady et al., 1999; Andrews et al., 2006). Oligo- dendrocytes are increasingly regarded to be critical for the survival system? and integrity of axons, possibly by providing trophic support or via axon-glia metabolic coupling mechanisms (Funfschilling et al., 2012; Oluich et al., 2012). This in turn has led to the widely held opinion in regenerative neurology, that myelin exerts an important neuropro- Clinical use of corticosteroid (CS) therapy and links with tective role on axons (and by extension, has a critical impact on dis- adverse neurological effects ease progression when the process is impaired). Indeed, deficiencies CS therapy is widely used in clinical practice worldwide, with ad- in myelin proteins have been demonstrated to lead to axonal