ICU病区泛耐药的鲍曼不动杆菌碳青霉烯类药物耐药基因分析.pdfVIP

J Med No．6 ·论 善· Res．Jun2012，V01．41 ICU病区泛耐药的鲍曼不动杆菌碳 青霉烯类药物耐药基因分析 陈士华魏取好 吕火烊 摘要 因型别及其流行情况，指导临床合理用药。方法 blaNDM一1和blalMP 绝大多数常规药物均有较高的耐药性，其耐药机制复杂，对碳青霉烯类耐药的耐药基因主要为blaOXA一23，亟待我们积极深入 地探索研究。 关键词泛耐药鲍曼不动杆菌基因型别PCR Resistantinthe Ac概cobacWrBaumannHfromICUWards．Chsn ofTheCarbapencmsGenes Pandrug—Resistant Shihua．Wei Analysls 0，Clinical Hospital，Zhejiang314200，China quhao，LvHuoyang．Depaame，ltLaboratory，PinghuPeople’s Abstract To the resistant of ofICUwardsisolatesofAcineto·· Objeetive earbapenemsgenotypespandrug——resistance investigate bacterbaumanniiinorderto ascientificbasisfortherationaluseofantibiotics．Methods20strainsof provide Totally AcinetobacterbaumanniiwerecollectedandtheminimuminhibitionconcentrationWaStestedwithE—testmethod．The resist· carbapenems moth— ant andblalMPwere PCR ofblaOXA一23，blaOXA一24，blaOXA一51，blaOXA一58，blaVIM，blaNDM一1performedby genotypcs baumanaiito od．ResultsTheresistanceratesof20strainsofAcinetobacter and wereall toami- 100％，but eiprofloxaein thoxazole B0．O％．PCR showedthat14 kacin 80％andto 55％。t