等离子喷涂钽涂层人工假体生物相容性研究.pdfVIP

19 4 Vol19, No4 2 0 1 1 2 O rthopedic ournal of China Feb2011 Expermi entalResearch * 李 矛,段永宏,尹大宇, 朱 澍,邵 为,朱锦宇, 朱庆生 (, 710032) : [] (Ta)[] (MTT),(Ta)[ ] : Ta, ;: Ta (RGR) ( 1132001) , (HA) ( 1105 003) (Ti) ( 1098 005) , (P 005), 0, L929 : Ta Ti(P 005), HA(P 005),Ta Ti , []Ta, : Ta, , , : R318 : A : 1005- 8478( 2011) 04- 0320- 05 R esearch on biocompatibility of artificial prosthesis w ith plasm asprayed tantalum coatingLI Mao, DUAN Yong hong, YIN Dayu, et al. Institute of Orthopaedics, X ijing osp ita,l theFourthM ilitaryM edical University, X i an 710032, China Abstract: [Objective]To investigate the possibility of artificial prosthesiswith plasma- sprayed tantalum (Ta) coating in clinicalapplication. [M ethod]Theauthoradoptedmorphologicalobservation and 3- (4, 5- dmi ethylthiazol- 2- yl) - 2, 5- di phenyltetrazolium brom ide (MTT) assay to evaluate thebiocompatibility of titanium (Ti) alloy (Ti- 6A1- 4V) with aTa coat ing about the cytotoxicity, cellular adhesion and celluarproliferation. [ Result]Themorphology of cells onTa coatingwas normal as in the control group. Results from the cytotoxicity expermi ent indicated that therewas no statisticaldifference among the Ta coating group ( 113. 2 0. 01), thehydroxyapatite(HA) coating group (110. 5 0. 03) and theTi coating group ( 109. 8 0. 05) in the relevant growth rate(P 0. 05), w ith the toxicitygradeof all in grade0, which showed thatTa coatingmaterial had no inhibitory effect on L929 cellgrowth. The cellular adhesion and proliferation expermi ent showed that the cells cultured