替莫唑胺白蛋白纳米粒的制备及其脑内递药特性研究.pdfVIP

中国医药工业杂志ChineseJoumalofPha丌Ilaceuticals · 41 · 2叭3，44(1) 替莫唑胺白蛋白纳米粒的制备及其脑内递药特性研究 金滔，彭花楠，姚金娜，戴东波，李范珠+ (浙江中医药大学药学院，浙江杭州310053) 摘要：以牛血清白蛋白为载体，采用高压均质法制备替莫唑胺白蛋白纳米粒，并运用脑微透析技术，考察该纳米粒经大鼠 剂组显著提高，但c…无显著差异。结果提示本品可延长药物在脑内的持续时间，促进药物的脑内吸收，有望成为替莫 唑胺脑部递药的有效载体。 关键词：替莫唑胺；白蛋白纳米粒；高压均质法；脑内递药；脑微透析技术 中图分类号：R944．9文献标志码：A 文章编号：100l一8255(2013)01一0041—05 a11d ofTemozololllide一10adedAlbuIlliIl Prep删ion B础DeliVe巧EValu撕on JIN Fanzhu+ Tao，PENGHuanan，YA0Jinna，DAI Dongbo，LI ChineseMedicdl tCollege可Phnrmdceuticni 3l005珀 Sc记nce．zhejinng Universi咿．Hnn晷zhou ABSTRACT：1’emozolomide-10adedalbumin were method nanoparticlespreparedbyhighpressurehomogenization with boVinesemmalbuminascarriermaterial．Thebrain behaViorsofthe iv deliVery preparednanopanicles toratswere brain resuItsshowedthatthe were with invest迦atedby micmdialysis the technique．The productsspherical diameter of(一14．70土3．51)mV of(52．16士2．23)％ aVerage of(117．60士3．40)nm，poteneialencapsulatione伍ciency and and temozolomide—loadedalbumin were of(5．33士0．10)％．Thefmax dmgloading AUCo一，of nanopaniclessigni6cantly withthetemozolomide no difl’erence．Theresults that improVedcompared solution，whilecm。。hadsigniflcant suggested the couldextendtheretentiontimeinbrainandincreasedthe in