《Microstructure Content and in vitro Release of Brucine and Strychnine in Strychnos NuxVomica Powder with Different Particle Sizes》.pdfVIP

Trans. Tianjin Univ. 2014, 20: 444-450 DOI 10.1007/s12209-014-2268-9 Microstructure, Content and in vitro Release of Brucine and Strychnine in Strychnos Nux-Vomica * Powder with Different Particle Sizes Ni Lijun (倪力军)，Zhao Wenwen (赵雯雯)，Zhang Liguo (张立国)，Wang Nannan (王南南) (School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China) © Tianjin University and Springer-Verlag Berlin Heidelberg 2014 Abstract ：To explore the effect of particle size on the quality uniformity and in vitro release performance of Strych- nos nux-vomica powder, seven samples of Strychnos nux-vomica powder with different particle sizes were prepared. Microstructures and particle sizes were analyzed, and high performance liquid chromatography (HPLC) was used to test the contents and in vitro release performances of brucine and strychnine in the samples. Results showed that the contents and the in vitro release rates of brucine (or strychnine) in different samples were different since there are different proportions of endosperms to epidermal cells in Strychnos nux-vomica powder with different particle sizes. Brucine and strychnine in each sample were promptly released in the first ten minutes and their cumulative release rates were higher than 70% after ten minutes. Eighty minutes later, the cumulative release rate tended to be a constant. Considering the quality uniformity and safety of Strychnos nux-vomica powder used as traditional Chinese medicine, it would be b