《Large animal models of human cauda equina injury and repair：evaluation of a novel goat model》.pdfVIP

NEURAL REGENERATION RESEARCH January 2015,Volume 10,Issue 1 SPECIAL ISSUE Large animal models of human cauda equina injury and repair: evaluation of a novel goat model 1 1, * 1, * 1 2 2 1 1 1 1, * Wen-tao Chen , Pei-xun Zhang , Feng Xue , Xiao-feng Yin , Cao-yuan Qi , Jun Ma , Bo Chen , You-lai Yu , Jiu-xu Deng , Bao-guo Jiang 1 Department of Trauma and Orthopedics, Peking University People’s Hospital, Beijing, China 2 Department of Radiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China Abstract *Correspondence to: Previous animal studies of cauda equina injury have primarily used rat models, which display Pei-xun Zhang, M.D., Ph.D., significant differences from humans. Furthermore, most studies have focused on electrophysio- zhangpeixun@126.com. logical examination. To better mimic the outcome after surgical repair of cauda equina injury, a Feng Xue, M.D., Ph.D., novel animal model was established in the goat. Electrophysiological, histological and magnetic drxuefeng@. resonance imaging methods were used to evaluate the morphological and functional outcome Bao-guo Jiang, M.D., Ph.D., after cauda equina injury and end-to-end suture. Our results demonstrate successful establish- jiangbaoguo@. ment of the goat experimental model of cauda equina injury. This novel model can provide detailed information on the nerve regenerative process following surgica