Biomaterials based on chitin and chitosan in wound dressing applications.pdfVIP

Biotechnology Advances 29 2011 322–337 Contents lists available at ScienceDirect Biotechnology Advances j ournal home Research review paper Biomaterials based on chitin and chitosan in wound dressing applications R. Jayakumar a,?, M. Prabaharan b, P.T. Sudheesh Kumar a, S.V. Nair a, H. Tamura c a Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidhyapeetham Univ ersity, Cochin-682 041, India b Department of Chemistry, Faculty of Engineering and Technology, SRM University, Kattankulathur-603 203, India c Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka-564-8680, Japan a r t i c l e i n f o a b s t r a c t Article history: Wound dressing is one of the most promising medical applications for chitin and chitosan. The adhesive Received 28 July 2010 nature of chitin and chitosan, together with their antifungal and bactericidal character, and their permeability Received in revised form 2 December 2010 to oxygen, is a very important property associated with the treatment of wounds and burns. Different Accepted 14 January 2011 derivatives of chitin and chitosan have been prepared for this purpose in the form of hydrogels, ?bers, Available online 22 January 2011 membranes, scaffolds and sponges. The purpose of this review is to take a closer look on the wound dressing applications of biomaterials based on chitin, chitosan and their derivatives in various forms in detail. Keywords: Chitin ? 2011 Elsevier Inc. All rights reserved. Chitosan Membranes Nano?bers Scaffolds Hydrogels Sponges Wound dressing Contents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 2. Chitin and chitosan ?bers . . . . . . . . . . . . . . . . . . .