Synthesis_2016_Hua_Fu_review_-_Copper-Catalyzed_Coupling_Reactions.pdf

ACCOUNT 745 Copper-Catalyzed Coupling Reactions Copper-Catalyzed Coupling ReactionsHonghua Rao, Hua Fu* Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. of China Fax +86(10 E-mail: fuhua@mail.tsinghua.edu.cn Received 11 November 2010 1 Introduction and Background Abstract: This account summarizes our recent developments in copper-catalyzed coupling reactions, including copper-catalyzed N-, O-, and P-arylations, the formation of carbon–nitrogen and carbon– Transition-metal-catalyzed cross-coupling reactions are carbon bonds via carbon–hydrogen bond activation, and the synthe- universal protocols in organic synthesis, and they provide sis of N-heterocyclic compounds. highly efficient transformations and allow the straightfor- ward, high-yielding, and scalable syntheses of organic 1 Introduction and Background compounds. In particular, the tolerant reactions can intro- 2 Copper-Catalyzed N-, O-, and P-Arylations duce certain functional groups with surgical precision.1 2.1 Copper-Catalyzed Synthesis of Primary Aromatic Amines 2.2 Copper-Catalyzed Synthesis of Phenols in Water Among such transition-metal-catalyzed cross-couplings, 2.3 Copper-Catalyzed N-Arylation of Aliphatic Amines and copper plays a significant role, and its use has greatly in-