功能化纳米粒子作为药物载体的研究.pdfVIP

2009 年第 67 卷 化 学 学 报 Vol. 67, 2009 第 19 期, 2205～2209 ACTA CHIMICA SINICA No. 19, 2205～2209 ·研究论文· 功能化纳米粒子作为药物载体的研究 李家诗a 张 琰a 陈 杰a 王朝华a 郎美东*,a,b (a 华东理工大学材料科学与工程学院 超细材料制备与应用教育部重点实验室 上海 200237) (b 复旦大学聚合物分子工程教育部重点实验室 上海 200433) 摘要 将合成的含有羧基侧基官能团的己内酯类聚合物, 用溶剂挥发与超声乳化相结合的方法制备成表面可供修饰的 纳米粒子. 利用扫描电镜(SEM)研究了纳米粒子在水溶液中的形态. 使用5-氟脲嘧啶(5-FU)作为模型药物制备了载药纳 米粒子, 利用紫外分光光度计法、差示扫描量热法(DSC)、X 射线衍射法(XRD)研究了纳米粒子的载药及释放性能. 研 究表明, 载药纳米粒子可以控制 5-FU 的释放速率. 释放时间可持续至 96 h 以上, 符合 Higuchi 动力学方程. 关键词 ε- 己内酯; 纳米粒子; 5-氟脲嘧啶; 药物载体 Research on Functional Nanoparticles as Drug Carrier Li, Jiashia Zhang, Yana Chen, Jiea Wang, Chaohuaa Lang, Meidong*,a,b a ( Key Laboratory for Ultrafine Materials, Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237) b ( Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Fudan University, Shanghai 200433) Abstract Carboxylic poly(ε-caprolactone) nanoparticles have been prepared by a emulsification/solvent evaporation method. The morphologies of the nanoparticles were investigated by scanning electron micro- scope (SEM). 5-Fluorouracil was employed as a model drug for the fabrication of drug loaded nanoparticles. UV spectrometer, differential scanning calorimeter (DSC) and X-ray diffraction (XRD) were adopted to study the entrapment and release behaviour. The results revealed that the release behaviour of 5-FU