均孔β-磷酸三钙骨支架的制备和表征.pdfVIP

均孔β-磷酸三钙骨支架的制备与表征 1 1 1 1 1,2 雷 力 ，万荣欣 ，胡帼颖 ，刘 欣 ，顾汉卿 （1. 天津医科大学天津市泌尿外科研究所，天津 300211；2. 上海交通大学医学院附属 第九人民医院，上海 200011 ） 摘要：挤出沉积快速成型技术因其极高的材料适用性和柔性显示了其在成形方面的优势。为研究骨组织工程支架 的孔结构，制备了符合浆料要求的微纳米 β-磷酸三钙(β-TCP)粉体和具有不同孔径的均孔支架。根据该技术对浆 料的要求，制备了具有良好分散性、稳定性的β-TCP 粉体和浆料。随着聚乙二醇(PEG20000)量的增加，所得粉体 纯度更高、结晶更完整、分散性更优；当pH=9.5 ，分散剂聚丙烯酸铵(PAA-NH )含量为1%(与粉体质量相比)时， 4 粉体在浆料中能够获得良好的分散稳定性。结合烧结工艺，通过挤出沉积成形技术制备了β-TCP 支架。调整工艺 参数，制备出具有均匀可控结构、良好联通性的支架，孔径范围在200-800μm 之间。 关键词：生物医用材料；均孔；快速成型；支架材料；聚乙二醇 Preparation and Characterization of Bone Scaffold of β-Tricalcium Phosphate with Mean Pore 1 1 1 1 1,2 LEI Li , WAN Rongxin , HU Guoying , LIU Xin , GU Hanqing (1. Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin, 300070, China；2. The Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai, 200011, China) Abstract: The technology based extrusion and deposition of the technology, because of its high adaptability and flexibility, shows the advantages on forming. In order to study the structure of the scaffold for bone tissue engineering β-Thricalcium phosphate （β-TCP ）powder and scaffold with different sizes of pore are prepared. According to the requirements of slurry, β-TCP powder and slurry with high concentration, good dispersibility and stability were prepared. With the increase of PEG20000, β-TCP were prepared with higher purity, crystalline state, better dispersion and when pH=9.5, the disper