单纯性肥胖青少年血清脂蛋白亚组分水平分析.docVIP

单纯性肥胖青少年血清脂蛋白亚组分水平分析 【摘要】 目的 探讨青少年单纯性肥胖与血清脂蛋白及其亚组分水平的关系。 方法 采用超速离心-高效液相色谱法测定60例肥胖青少年和19例体重指数正常者血清脂蛋白及其亚型水平。使用双能量X线吸收仪检测所有受试者全身及躯干部体脂比率。结果 与正常对照组相比，肥胖组血清TC（4.47±0.90） 比 （3.79±0.50）mmol/ L、TG（1.02±0.41） 比 （0.72±0.34）mmol/ L、LDLC（2.56±0.81） 比 （1.95±0.35）mmol/ L、LDLaC（2.39±0.83） 比 （1.74±0.37） mmol/ L平均水平显著增高, 而HDLC（1.18±0.23） 比 （1.35±0.16）mmol/ L、HDL2C（0.73±0.21） 比 （0.91±0.16） mmol/ L平均水平明显降低（P 0.01）。BMI、腰围、全身体脂及躯干体脂比率分别与TC、TG、LDLC、LDLaC水平呈显著正相关，与HDLC、HDL2C水平呈显著负相关（P 0.05，P0.01）。结论 单纯性肥胖青少年存在与肥胖相关的早期脂质代谢紊乱的趋势。 【关键词】 肥胖病学; 青少年；脂蛋白类,LDL Analysis of serum lipids and its subfractions levels in obese adolescents GUO Hanbang, SUN Mingxiao, HUANG Xiuqing, DONG Jun,LI Hongxia,MAN Yong, WANG Shu, LI Jian. 1. Beijing Institute of Geriatrics, Beijing Hospital,Beijing 100730,China 2.Department of Endocrinology and Metabolism,Beijing Hospital,Beijing 100730,China Abstract： Objective To investigate the relationship between the distribution of lipoproteins subfractions and obesity in adolescents. Methods The subfractions of lipoproteins were determined by ultracentrifugation and highperformance liquid chromatiography in 60 obese and 19 normal adolescents. The percentage of body fat was detected by DEXA. Results The serum levels of TC（4.47±0.90） vs （3.79±0.50）mmol/ L、TG（1.02±0.41）vs （0.72±0.34）mmol/ L、LDLC（2.56±0.81） vs （1.95±0.35）mmol/ L、LDLaC(2.39±0.83） vs （1.74±0.37）mmol/ L were significant higher and the serum levels of HDLC （1.18±0.23） vs （1.35±0.16）mmol/ L、HDL2C（0.73±0.21） vs （0.91±0.16）mmol/ L were significant lower in obesity group compared with normal group （P 0.01）. The BMI, waistline and percentages of body fat in whole and trunk were positive correlated with serum levels of TC, TG, LDLC, LDLaC, and negative correlated with serem levels of HDLC and HDL2C（all P 0.05 or P0.01）. Conclusions There are trends of abnormal distribution of serum lipids in obese adolescents. Key words： Bariatrics; Adolescent; Lip