功能高分子在新型给药系统中的应用.pdfVIP

2112 精 细 化 工 Vol. 21, No. 12 200412 FINE CHEMICALS Dec. 2 0 0 4 丁富新, 江田民, 昝 佳, 蒋国强, 谭丰苹 ( , 100084) : , ; , , : ; ; ; ; ; : R97 :A : 1003- 5214( 2004) 012- 0923- 05 A Review of the Application of Smart Polymer in New Drug Delivery Sy tem DING Fuxi , JIANG T ia mi , ZAN Jia, JIANG Guoqia g, TAN Fe gpi g ( Dep ar tment of Chemical E ng ineer ing , Tsingh ua Univ ersity , Be ij ing 100084, Ch ina) Ab tract:The ew drug delivery systems should keep the drug at a desired therapeutic level i the body w hile avoidi g the eed for freque t admi istratio . With the rapid developme t of drug delivery systems, more a d more smart polymers with u ique characteristics have bee sy thesized a d used as the key materials i these systems, a d the i tegra ts of the polymer play importa t role i co trolled drug release processes. A review of the applicatio of smart polymers i drug delivery systems is give i this article, with the emphasis o the fu ctio a d role of smart polymers i drug release processes. The progress a d further applicatio s of smart polymers i this area are discussed. Key word : smart polymer; drug delivery; osmotic pump; sitespecific; microe capsulate; impla t Foundation item: Gra ted by the atio al atural scie ce fou datio ( a d research fou datio of mi istry of educatio ( 20020003056) , 1 , , , , , , [ 1] ,