CADD-and-Molecular-Modeling文献.pptVIP

ACE distance map 4 points defined Five distances defined Donor Hydrophobic core Charged negative Acceptor deoxy nucleoside triphosphate (dNTP) 2,3 dideoxy nucleoside 3-azido thymidine (AZT) 2,3- didehydro dideoxy nucleoside 3-nitro nucleoside MESP contours for nucleosidic drugs. Red coloured contours indicate a value of -.01 for electrostatic potential and yellow contours indicate a value of -0.05 Pharmacophoric Features of Nucleosidic HIV-1RT Inhibitors Concluding remarks on Nucleosidic inhibitors Different substituents at the 3? position show similar sugar ring puckering and only slight