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《1型糖尿病的干细胞治疗研究进展》.pdf
19 4 Vol. 19, No. 4
2007 8 Chinese Bulletin of Life Sciences Aug., 2007
1004-0374(2007)04-0401-08
· ·
1
(121001)
1 β
β
1
1
R58.71; Q813 A
Advancements of stem-cell therapy for type 1 diabetes mellitus
LI Hongdan, WEI Jia, MU Changzheng*
(Liaoning Medical College, Jinzhou 121001, China )
Abstract: Type 1 diabetes is characterized by the selective destruction of pancreatic β-cells caused by an
autoimmune attack. Restoration of damaged β-cells by transplantation from exogenous sources or by endocrine
pancreas regeneration would be ideal therapeutic options. Stem cells of both embryonic and adult origin offer
some interesting alternatives, taking into account the latest advances indicating that these cells could be the
potential building blocks from which insulin secreting cells could be obtained in vitro under appropriate culture
conditions. Although it has been reported that insulin-producing cells derived from stem cells have been
shown to reverse experimentally induced diabetes in animal models, several concerns need to be solved before
finding a definite medical application. These refer mainly to the obtainment of a cell population as similar as
possible to pancreatic β-cells, and to the problems related with the immune compatibility and tumor formation.
This review will describe the different approaches that have been used to obtain insulin-producing cells f
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