DNA识别受体的研究进展徐丽.pdfVIP

h ttp: / /www. b io ther. o rg Ch in J Cancer B iother, F eb. 2010, V ol. 17, N o. 1 99 DOI: 10. 3872/ j. issn. 1007385X. 2010. 01. 020 综述 DNA 徐 丽 综述, 曹雪涛审阅 (第二军医大学 免疫学研究所, 医学免疫学国家重点实验室 上海 200433 [ ] DNA TLR 9 TLR 9 : ( 1 TLR9; ( 2 TLR 9; ( 3 TLR 9; ( 4 TLR9 DNA , T LR 9 TLR 9 TLR9 DNA , 3 : DA I A IM 2RNA [ ] DNA; ; TLR9; DA I; A IM 2; RNA [ ] R 392. 1 [ ] A [] 1007385X ( 2010 0 1009905 Advances in DNA recognition receptors XU L ,i CAO Xuetao ( Inst itute of Immuno logy, S econd M ilitaryM ed ical U n iversity; N at iona lK ey Laboratory of M ed ical Immuno logy, Sh anghai 200433, Ch ina [A stract] DNA, as the material b as is of all liv ing cells, triggers innate mi m un e responses th rough TLR 9 and other cy toso lic recogn ition recep tors. In recent years, the research progress of TLR 9 is m ain ly m an ifested by th e follow ing fou r as p ects: ( 1 th e determ inants of TLR9 interacting w ith its ligands; ( 2 the m echan ism s and the mi portan ce of TLR9 tran s location from th e endop lasm ic reticu lum to th e endosom e; ( 3 the roles o f the endosom al acid ification and m atu ration, and subsequent TLR9 cleavage in TLR 9 s ign al transduction pathw ay; and ( 4 the poss ib le m echan ism s by w h ich the organ ism d istingu ish self DNA from m icrob ial DNA. M eanw h ile, a series of exp ermi ents on TLR9 antagon ists and TLR9 deficient m ice confirm ed the p resence of TLR9indep end ent cytosolic DNA sen sors. So far, th ree TLR9independent DNA sensors h ave been found, and they are DA I, A IM 2, and RNA polym erase . [K ey words] DNA; TLR 9; DA I; A IM 2; RNA polymerase [ Ch in J Can cer B iother, 2010, 17( 1 : 99103] 40 , , T IR ( To ll/ IL1 receptor hom o logou s [ 1] ,