谁在承担未成熟大鼠海马神经元和突触损伤的保护责任？.docVIP

谁在承担未成熟大鼠海马神经元及突触损伤的保护责任？ 1,6-二磷酸果糖是一种促进细胞代谢的中间物否减轻反复热性惊厥导致的1,6-二磷酸果糖注射线粒体肿胀、粗面内质网脱颗粒以及高尔基体扩张能显著缩小突触间隙宽度增加突触活性带长度突触后致密区厚度及突触界面曲率。提示。 透射电镜下可见，100 mg/100 g 1,6-二磷酸果糖注射可减轻粗面内质网脱颗粒 Article: Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate, by Jianping Zhou1, Fan Wang2, Jun Zhang3, Hui Gao4, Yufeng Yang5, Rongguo Fu6 (1 Department of Pediatrics, the Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China; 2 Department of Obstetrics and Gynecology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi Province, China; 3 Department of Gastroenterology, the Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China; 4 Department of Anesthesiology, Yanan University Affiliated Hospital, Yan’an, Shaanxi Province, China; 5 Editorial Board of Chinese Journal of Child Health Care, Xi’an, Shaanxi Province, China; 6 Department of Nephrology, the Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China) Zhou JP, Wang F, Zhang J, Gao H, Yang YF, Fu RG. Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate. Neural Regen Res. 2014;9(9):937-942. 欲获更多资讯： Neural Regen Res Who are responsible for protecting against neuron and synapse injury in immature rats? Fructose-1,6-diphosphate is a metabolic intermediate that promotes cell metabolism. Whether it can alleviate hippocampal neuronal injury caused by febrile convulsion remains unclear. Dr. Jianping Zhou, the Second Affiliated Hospital, Medical College of Xian Jiaotong University, China and his team established a repetitive febrile convulsion model in rats aged 21 days, equivalent to 3–5 years in humans, intraperitoneally administered fructose-1,6-diphosphate at 1,000 mg/kg into the rat model. Result