谁在加重急性脑缺血时海马神经元损伤.docVIP

谁在加重急性脑缺血时海马神经元损伤.doc

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谁在加重神经元损伤脑缺血急性期细胞外信号调节激酶可出现激活现象利用糖尿病大鼠经典的四血管结扎脑缺血动物模型,细胞外信号调节激酶特异性抑制剂对糖尿病脑缺血再灌注大鼠进行预处理细胞外信号调节激酶细胞外信号调节激酶活性降低 苏木精-伊红染色显示,抑制通路糖尿病大鼠脑缺血海马CA1区存活神经细胞数量减少 Article: Regulation of extracellular signal-regulated kinase 1/2 infuences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia, by Yaning Zhao1, Jianmin Li2, Qiqun Tang1, Pan Zhang1, Liwei Jing1, Changxiang Chen1, Shuxing Li1 (1 College of Rehabilitation, Hebei United University, Tangshan, Hebei Province, China; 2 Affliated Hospital of Hebei United University, Tangshan, Hebei Province, China) Zhao YN, Ji JM, Tang QQ, Zhang P, Jing LW, Chen CX, Li SX. Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia. Neural Regen Res. 2014;9(7):749-756. 欲获更多资讯: Neural Regen Res What aggravates hippocampal neuronal injury in acute cerebral ischemia? Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute cerebral ischemia. Yaning Zhao and her colleagues, Hebei United University, China induced transient whole-brain ischemia by four-vessel occlusion in normal and diabetic rats and intravenously injected diabetic rats with extracellular signal-regulated kinase 1/2 30 minutes before ischemia as a pretreatment. Results showed that during the pathological progression of cerebral ischemia/reperfusion in rats, activation of extracellular signal-regulated kinase 1/2 exhibits protective effect on neuronal injury. Reduced extracellular signal-regulated kinase 1/2 decreases Ku70 activity, increases Bax expression and thereby increases the number of lost hippocampal neurons in diabetic rats after cerebral ischemia/reperfusion. These results were published in Neural Regeneration Research (Vol. 9, No. 7, 2014). Hematoxylin-eosin staining reveals that inhibition of extracellular signal-regulated kinase 1/2 activity aggravates neuronal loss in the hippocampal CA1 region in a diabetic rat after cerebral isch

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