益智健脑中药治疗阿尔茨海默病抑制神经元凋亡机制.docVIP

益智健脑治疗阿尔茨海默病的机制前期研究发现能够改善患者的认知功能进一步的研究发现益智健脑认知功可能是通过抑制神经元凋亡、减少tau蛋白磷酸化、减轻神经炎症。采用益智健脑颗粒浓缩液干预，分离颞叶组织寻找差异表达蛋白。其功能分别涉及调节β蛋白的生成、氧化应激、神经炎症、Tau蛋白磷酸化的调节、神经元凋亡的调节7月第13期。 快速老化小鼠P8颞叶差异蛋白中10号蛋白质点Chaperonin containing TCP1,subunit 2）的肽质量指纹图谱Article: Treating Alzheimer’s disease with Yizhijiannao granules by regulating expression of multiple proteins in temporal lobe, by Hong Zhu1, Liuyang Luo2, Sihang Hu1, Keli Dong1, Guangcheng Li1, Ting Zhang1 (1Department of Traditional Chinese Medicine, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, China; 2 Department of Emergency, Bao-an District Hospital of Traditional Chinese Medicine, Shenzhen, Guangdong Province, China) Zhu H, Luo LY, Hu SH, Dong KL, Li GC, Zhang T. Treating Alzheimer’s disease with Yizhijiannao granules by inhibiting neuronal apoptosis. Neural Regen Res. 2014;9(13):1283-1287. 欲获更多资讯： Neural Regen Res Treating Alzheimer’s disease with Yizhijiannao granules by inhibiting neuronal apoptosis Previous studies have shown that Yizhijiannao granule can enhance cognitive performance in Alzheimer’s disease patients and Alzheimer’s disease-model mice. Further studies revealed that Yizhijiannao granule may exert its therapeutic effect by inhibiting neural cell apoptosis, reducing tau phos-phorylation and relieving neuroinflammation. Dr. Hong Zhu and colleagues who come from Third Xiangya Hospital of Central South University, China treated senescence-accelerated mouse prone 8 mice with Yizhijiannao granule, aiming to identify target-proteins of Yizhijiannao granule that were particularly related to the treatment of Alzheimer’s disease. Thirty-seven differential protein spots were found in the temporal lobe area, and finally 10 protein spots were identified. These proteins are separately involved in the regulation of amyloid beta production, oxidative stress, neuroinflammation, regulation of tau phosphorylation, and regulation of neuronal apoptosis. The relevant study has been published in the Neu