海马磁共振波谱分析在颞叶癫痫症中的价值.pdfVIP

海马磁共振波谱分析在颞叶癫痫症中的价值 李伟 龙晚生 罗学毛 陈曼琼 兰勇 何义改 目的探讨海马氢质子磁共振波谱分析 (1H-MRS)在颞叶癫痫症 中的应用价值 。方 法采用PhilipsAchieva1.5T双梯度磁共振扫描仪，对38例颞叶癫痫患者和20例健康志愿者行 颅脑MRI和海马1H-MRS检查，观察NAA、Cr、Cho浓度和NAA/(Cho+Cr)、NAA/Cr和NAA/Cho值。 分别对癫痫患者病灶侧与正常侧，病灶侧与正常对照组海马的NAA/(Cho+Cr)、NAA/Cr和NAA/Cho 值进行t检验，分析两者之间差异有无显著性。结果癫痫患者组癫痫侧、正常侧和对照组海马 的NAA/(Cho+Cr)值分别为(0.42±0.06)、(0.67±0.09)、(0.72±0.07),癫痫组癫痫侧与正常侧、对 照组比较差异有显著性 （P＜0.05），而正常侧与对照组比较差异无显著性(P＞0.05)。以NAA/ (Cho+Cr)来检出癫痫，灵敏度曲线呈现低→高→低的变化，在0.60时，灵敏度最高。结论1H- MRS不仅能早期诊断海马硬化，而且可进一步提高术前癫痫灶定位的准确性。 海马；磁共振；氢质子波谱；癫痫 Valueofhippocampalmagneticresonancespectroscopyintemporallobeepilepsydis ease LIWei LONGWan-shengLUOXue-mao CHENMan-qiongLANYong HEYi-gaiDepart mentofRadiology,JiangmenCentralHospital,Jiangmen529030,China Objective Tostudytheapplicationvalueofhippocampusprotonmagneticreso nancespectroscopy(1H-MRS)intemporallobeepilepsy.Methods WithPhilipsAchieva1.5Tdual gradientMRscanner,38patientswithtemporallobeepilepsyand20healthyvolunteerswereunderwent brainMRIandhippocampal1H-MRSexamination,observationindicatorsincludedtheconcentrationof NAA,Cr,ChoandthevalueofNAA/(Cho+Cr),NAA/CrandNAA/Cho.TheNAA/(Cho+Cr),NAA.Crand NAA/Chovaluesinhippocampusofepilepsysideofepilepsygroup,thenormalsideofepilepsygroup,and thenormalcontrolgrouphadattest,analyzingthestatisticaldifferencebetweenthetwogroups.Results TheNAA/(Cho+Cr)valuesinhippocampaloftheepilepsysideofepilepticpatients,thenormalsideof epilepticpatientsandthecontrolgroupwere(0.42+0.06),(0.67+0.09),(0.72+0.07),respectively,therewas significantdifferencebetweentheepilepsysideandthenormalsideofepilepticpatients,andbetweenthe epilepsysideofepilepticpatientsandthecontrolgroup(P＜0.05),butnosignificantdifferencebetweenthe normalsideofepilepticpatientsandthecontrolgroup(P＞0.05).UsingNAA/(Cho+Cr)todetectepilepsy,the sensitivitycurveshowedlow→high→lowchanges,thehighestsensitivityappearedin0.60.Conclusion 1H-MRS