喷雾干燥法制备神经毒素壳聚糖鼻腔给药微球研究.docVIP

喷雾干燥法制备神经毒素壳聚糖微球蔡鑫君，( (浙江中医药大学药学院，浙江杭州 310053)壳聚糖浓度为0.75％，壳聚糖-TPP重量比为101，进口温度105℃，空气流速550L/h(19.23±0.42)％(92.10±2.1)％(6.86±0.76)μm。体外释药Higuchi模型拟合方程Q=11.4t1/2-5.89(r=0.9920)，表明该微球具有缓释作用。关键词：喷雾干燥法；神经毒素；壳聚糖微球；体外释放 of Chitosan Microspheres Loaded with Neurotoxin-Ⅰfor Nasal Delivery by Spray Drying Technique CAI Xin-jun, XIA Ai-xiao, CHAI Guo-bao,WEI Ying-hui, Fen Jian,LI Fan-zhu* (College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053) ABSTRACT: OBJECTIVE To prepare the preparation of neurotoxin-Ⅰloaded chitosan microspheres and to investigate the drug release beh