氧化苦参碱和拉米夫定在Beagle犬体内的药物动力学相互作用的研究.docVIP

氧化苦参碱与拉米夫定在Beagle犬体内的药物动力学相互作用研究 刘晓红 孙英华 孙进 何仲贵※（沈阳药科大学 药学院 生物药剂学研究室，辽宁 沈阳，110016Single-dose pharmacokinetics of lamivudine and oxymatrine administrated alone and in combination to beagle dogs Xiaohong Liu, Yinghua Sun, Jin Sun, Zhonggui He※(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China) ABSTRACT: OBJECTIVE To evaluate the single-dose pharmacokinetic interaction of lamivudine and oxymatrine in combination to beagle dogs, both of drugs which are active against hepatitis B virus and which exert synergetic antiviral effect by co-administration. METHODS A randomiz